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Article

p53 restoration kills primitive leukemia cells in vivo and increases survival of leukemic mice.

Cell cycle (Georgetown, Tex.) - 1 Jan 2013

Velasco-Hernández Talía, Vicente-Dueñas Carolina, Sánchez-García Isidro, Martin-Zanca Dionisio

Abstract excerpt

Loss of p53 function is a common feature of human cancers and it is required for differentiated tumor cell maintenance; however, it is not known whether sustained inactivation of the p53 pathway is needed for cancer stem cell persistence. Chronic myeloid leukemia (CML) is caused by a chromosome translocation that generates the BCRABL oncogene encoding a constitutively active protein tyrosine kinase. The disease...

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Identifiers

PMID: 23255106
DOI: 10.4161/cc.23031
PMCID: PMC3570500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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