Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.

Molecular and cellular biology - 1 Mar 1997

Prisco M, Hongo A, Rizzo M G, Sacchi A, Baserga R

Abstract excerpt

The wild-type p53 protein is known to modulate apoptosis induced in 32D murine hemopoietic cells by interleukin-3 withdrawal. In 32D cells and in 32D cells constitutively expressing a temperature-sensitive mutant of p53 (32Dtsp53), overexpression of a wild-type (but not a mutant) insulin-like growth factor I receptor (IGF-IR) protects these cells from apoptosis. A tsp53 in its wild-type conformation causes a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Line
Share to Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Promoter Regions, Genetic

Share to Temperature

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 9032235
DOI: 10.1128/MCB.17.3.1084
PMCID: PMC231833

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.PMID 9032235Read ↗

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis.Semantic proximity Read ↗

IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway.Semantic proximity Read ↗

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.Semantic proximity Read ↗

Regulation of p53-mediated apoptosis and cell cycle arrest by Steel factor.Semantic proximity Read ↗

Regulation of Id2 gene expression by the type 1 IGF receptor and the insulin receptor substrate-1.Semantic proximity Read ↗

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.Semantic proximity Read ↗

Ligand- and kinase activity-independent cell survival mediated by the epidermal growth factor receptor expressed in 32D cells.Semantic proximity Read ↗

Anti-apoptotic activity of low levels of wild-type p53.Semantic proximity Read ↗

Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells.Semantic proximity Read ↗

p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1.Semantic proximity Read ↗

Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.Semantic proximity Read ↗

p53-induced inhibition of protein synthesis is independent of apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.