The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.

doi:10.1128/MCB.17.3.1084

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Article

The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal.

Molecular and cellular biology - 1 Mar 1997

Prisco M, Hongo A, Rizzo M G, Sacchi A, Baserga R

Abstract excerpt

The wild-type p53 protein is known to modulate apoptosis induced in 32D murine hemopoietic cells by interleukin-3 withdrawal. In 32D cells and in 32D cells constitutively expressing a temperature-sensitive mutant of p53 (32Dtsp53), overexpression of a wild-type (but not a mutant) insulin-like gro...

Topics

Animals
Apoptosis
Cell Line
Cytomegalovirus
Hematopoietic Stem Cells
Humans
Interleukin-3
Mice
Mutation
Promoter Regions, Genetic
Rats
Receptor, IGF Type 1
Temperature
Tumor Suppressor Protein p53

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