Article
Anti-apoptotic activity of low levels of wild-type p53.
The EMBO journal - 2 Sept 1996
Lassus P, Ferlin M, Piette J, Hibner U
Abstract excerpt
Induction of apoptosis is a function of both an external stimulus and the physiology of the cell, which includes the expression of multiple oncogenes and tumor suppressors. Here we have studied the apoptotic response of immortalized mouse fibroblasts to serum withdrawal. We show that, in addition to the p53-independent apoptosis observed in p53- cells, overexpression of wild-type p53 tumor suppressor results in a...
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