Article
Retroviral transduction of hematopoietic progenitor cells with mutant p53 promotes survival and proliferation, modifies differentiation potential and inhibits apoptosis.
Leukemia - 1 Oct 1996
Shounan Y, Dolnikov A, MacKenzie K L, Miller M, Chan Y Y, Symonds G
Abstract excerpt
Mutations in the p53 tumor suppressor gene have been shown to be associated with many human tumors and various leukemias and lymphomas. To examine whether constitutive overexpression of mutant p53 can effect transformation of normal hematopoietic cells, a mutant p53 gene was introduced into norma...
Topics
- Animals
- Apoptosis
- Base Sequence
- Cell Differentiation
- Cell Line
- Cell Survival
- Female
- Gene Transfer Techniques
- Genes, p53
- Hematopoietic Stem Cells
- Humans
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Retroviridae