Article
Delayed expression of apoptosis in X-irradiated human leukemic MOLT-4 cells transfected with mutant p53.
Journal of radiation research - 1 Jun 2003
Nakano Hisako, Yonekawa Hiromichi, Shinohara Kunio
Abstract excerpt
The effects of X-rays on cell survival, apoptosis, and long-term response in the development of cell death as measured by the dye exclusion test were studied in human leukemic MOLT-4 cells (p53 wild-type) stably transfected with a mutant p53 cDNA expression vector. Cell survival, as determined from colony-forming ability, was increased in an expression level dependent manner, but the increase was partial even...
Topics
- Apoptosis
- Humans
- Leukemia, Lymphoid
- Mutation
- Time Factors
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53