Reconstitution of wild-type p53 expression triggers apoptosis in a p53-negative v-myc retrovirus-induced T-cell lymphoma line.

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Article

Reconstitution of wild-type p53 expression triggers apoptosis in a p53-negative v-myc retrovirus-induced T-cell lymphoma line.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Jun 1993

Wang Y, Ramqvist T, Szekely L, Axelson H, Klein G, Wiman K G

Abstract excerpt

Inactivation or mutation of the p53 tumor suppressor gene has been observed in a wide variety of human and murine tumors. We have found that a v-myc retrovirus (J3)-induced T-cell lymphoma line (J3D) has lost one of its p53 alleles, whereas the other has become inactivated due to the insertion of...

Topics

Alleles
Animals
Apoptosis
Cell Transformation, Viral
Gene Deletion
Gene Expression Regulation, Neoplastic
Genes, myc
Genes, p53
Lymphoma, T-Cell
Mice
Moloney murine leukemia virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Insertional

Recombinant Fusion Proteins

Transfection

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Virus Integration

Source

Open in PubMed

Identifiers

PMID: 8373731

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8373731-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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