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Article

Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and inhibition of Bim expression.

FEBS letters - 3 Jan 2005

Rosas Marcela, Birkenkamp Kim U, Lammers Jan-Willem J, Koenderman Leo, Coffer Paul J

Abstract excerpt

Phosphatidylinositol 3-kinase (PI3K) and its effector protein kinase B (PKB/c-akt) have been implicated as critical mediators of cytokine-induced survival signals. In this study, we have utilized an IL-5 dependent hematopoietic cell line (TF-1) to investigate the signaling events involved in cytokine-dependent erythroblast survival. We demonstrate that IL-5 rescues TF-1 cells from apoptosis through a...

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PMID: 15620712
DOI: 10.1016/j.febslet.2004.11.074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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