Article
Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.
The EMBO journal - 16 Jan 1995
Kinoshita T, Yokota T, Arai K, Miyajima A
Abstract excerpt
Interleukin 3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF) exert their biological functions through acting on a specific receptor which consists of a ligand-specific alpha subunit and the shared common beta subunit. Inhibition by genistein of a subset of IL-3/GM-CSF-mediat...
Topics
- Animals
- Apoptosis
- Cell Cycle
- Cell Line
- Cell Nucleus
- DNA
- Gene Expression Regulation
- Genistein
- Hematopoietic Stem Cells
- Interleukin-3
- Isoflavones
- Mice
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Proto-Oncogenes