Article
Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.
The EMBO journal - 16 Jan 1995
Kinoshita T, Yokota T, Arai K, Miyajima A
Abstract excerpt
Interleukin 3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF) exert their biological functions through acting on a specific receptor which consists of a ligand-specific alpha subunit and the shared common beta subunit. Inhibition by genistein of a subset of IL-3/GM-CSF-mediated signals, including c-myc induction, resulted in the abrogation of DNA synthesis, however, IL-3 still protected cells...
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