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Article

A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation.

The Journal of biological chemistry - 11 Mar 1994

Taccioli G E, Cheng H L, Varghese A J, Whitmore G, Alt F W

Abstract excerpt

Lymphocyte antigen receptor variable regions are encoded by gene segments that are assembled by the site-specific variable (diversity) joining (V(D)J) recombination process. We have assayed the V-3 Chinese hamster ovary cell line, which has a double-strand DNA break repair (dsbr) defect, for the ability to carry out V(D)J recombination following transfection of constructs that encode the RAG-1 and RAG-2 proteins...

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PMID: 8125964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation.PMID 8125964Read ↗

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