Article
A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation.
The Journal of biological chemistry - 11 Mar 1994
Taccioli G E, Cheng H L, Varghese A J, Whitmore G, Alt F W
Abstract excerpt
Lymphocyte antigen receptor variable regions are encoded by gene segments that are assembled by the site-specific variable (diversity) joining (V(D)J) recombination process. We have assayed the V-3 Chinese hamster ovary cell line, which has a double-strand DNA break repair (dsbr) defect, for the...
Topics
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- DNA Repair
- DNA-Binding Proteins
- Genetic Complementation Test
- Homeodomain Proteins
- Hybrid Cells
- Mice
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Proteins
- Recombination, Genetic
- Severe Combined Immunodeficiency