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Article

Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines.

Molecular and cellular biology - 1 Oct 2000

Lew S, Franco D, Chang Y

Abstract excerpt

V(D)J recombination is the mechanism by which antigen receptor genes are assembled. The site-specific cleavage mediated by RAG1 and RAG2 proteins generates two types of double-strand DNA breaks: blunt signal ends and covalently sealed hairpin coding ends. Although these DNA breaks are mainly resolved into coding joints and signal joints, they can participate in a nonstandard joining process, forming hybrid and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte, Light Chain

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Source

Open in PubMed Open full text

Identifiers

PMID: 10982833
DOI: 10.1128/MCB.20.19.7170-7177.2000
PMCID: PMC86270

Genes

RAG1
RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines.PMID 10982833Read ↗

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