Article
scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1991
Biedermann K A, Sun J R, Giaccia A J, Tosto L M, Brown J M
Abstract excerpt
C.B-17 severe combined immunodeficient (scid) mice carry the scid mutation and are severely deficient in both T cell- and B cell-mediated immunity, apparently as a result of defective V(D)J joining of the immunoglobulin and T-cell receptor gene elements. In the present studies, we have defined the tissue, cellular, and molecular basis of another characteristic of these mice: their hypersensitivity to ionizing...
Topics
- Animals
- Cell Survival
- Cells, Cultured
- DNA
- DNA Damage
- DNA Repair
- Dose-Response Relationship, Radiation
- Fibroblasts
- Gamma Rays
- Immunologic Deficiency Syndromes
- Mice