Article
Complementation of the radiosensitive phenotype in severe combined immunodeficient mice by human chromosome 8.
Cancer research - 15 Dec 1993
Kirchgessner C U, Tosto L M, Biedermann K A, Kovacs M, Araujo D, Stanbridge E J, Brown J M
Abstract excerpt
Severe combined immunodeficient (scid) C.B-17 mice are deficient in variable (diversity) joining region recombination, the process of assembling the immunoglobulin and T-cell receptor genes from gene segments, thereby creating much of the enormous diversity of antigen-binding capacity, scid mice are also sensitive to ionizing radiation, as a result of their deficiency in double-strand break repair. Here we report...
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