Article
T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990
Petrini J H, Carroll A M, Bosma M J
Abstract excerpt
The severe combined immune deficient (scid) mouse mutant is characterized by a general absence of functional B and T lymphocytes. This deficiency appears to result from a defect in the variable-diversity-joining (VDJ) recombinase system, which is responsible for the assembly of V, D, and J gene s...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Clone Cells
- DNA
- DNA Nucleotidyltransferases
- Gene Rearrangement, T-Lymphocyte
- Immunologic Deficiency Syndromes
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Oligonucleotide Probes
- Phenotype
- Polymerase Chain Reaction