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Article

A link between double-strand break-related repair and V(D)J recombination: the scid mutation.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 1991

Hendrickson E A, Qin X Q, Bump E A, Schatz D G, Oettinger M, Weaver D T

Abstract excerpt

We show here that mammalian site-specific recombination and DNA-repair pathways share a common factor. The effects of DNA-damaging agents on cell lines derived from mice homozygous for the scid (severe combined immune deficiency) mutation were studied. Surprisingly, all scid cell lines exhibited a profound hypersensitivity to DNA-damaging agents that caused double-strand breaks (x-irradiation and bleomycin) but...

Topics

Animals
Animals, Newborn
Bleomycin
DNA Damage
DNA Repair
Fibroblasts
Immunologic Deficiency Syndromes
Kinetics
Mice
Mice, Inbred BALB C
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1709732
DOI: 10.1073/pnas.88.10.4061
PMCID: PMC51597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1709732-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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