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Article

Impairment of V(D)J recombination in double-strand break repair mutants.

Science (New York, N.Y.) - 9 Apr 1993

Taccioli G E, Rathbun G, Oltz E, Stamato T, Jeggo P A, Alt F W

Abstract excerpt

Cells maintain the integrity of their genome through an intricate network of repair systems that recognize and remove lesions from DNA. The only known site-directed recombination process in vertebrates is the V(D)J recombination of lymphocyte antigen receptor genes. A large panel of cell lines deficient in DNA repair were tested for the ability to perform V(D)J recombination after introduction of the RAG-1 and...

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Identifiers

PMID: 8469973
DOI: 10.1126/science.8469973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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