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Article

Analysis of the defect in DNA end joining in the murine scid mutation.

Molecular and cellular biology - 1 Oct 1992

Harrington J, Hsieh C L, Gerton J, Bosma G, Lieber M R

Abstract excerpt

Murine severe combined immune deficiency (scid) is marked by a 5,000-fold reduction in coding joint formation in V(D)J recombination of antigen receptors. Others have demonstrated a sensitivity to double-strand breaks generated by ionizing radiation and bleomycin. We were interested in establishing the extent of the defect in intramolecular and intermolecular DNA end joining in lymphoid and nonlymphoid cells from...

Topics

Animals
Base Sequence
Cell Line
DNA
DNA Mutational Analysis
DNA Repair
Fibroblasts
Gene Rearrangement, T-Lymphocyte
Genome
Lymphocytes
Mice
Mice, SCID

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Sequence Homology

Severe Combined Immunodeficiency

Source

Open in PubMed Open full text

Identifiers

PMID: 1406659
DOI: 10.1128/mcb.12.10.4758-4768.1992
PMCID: PMC360403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1406659-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analysis of the defect in DNA end joining in the murine scid mutation.PMID 1406659Read ↗

Activation of V(D)J recombination induces the formation of interlocus joints and hybrid joints in scid pre-B-cell lines.Semantic proximity Read ↗

Defective repair of radiation-induced chromosomal damage in scid/scid mice.Semantic proximity Read ↗

A link between double-strand break-related repair and V(D)J recombination: the scid mutation.Semantic proximity Read ↗

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.Semantic proximity Read ↗

Temporally uncoupled signal and coding joint formation in human V(D)J recombination.Semantic proximity Read ↗

Failure of hairpin-ended and nicked DNA To activate DNA-dependent protein kinase: implications for V(D)J recombination.Semantic proximity Read ↗

The influence of DNA double-strand break structure on end-joining in human cellsSemantic proximity Read ↗

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.Semantic proximity Read ↗

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Chromosome Instability as a Result of Double-Strand Breaks near Telomeres in Mouse Embryonic Stem CellsSemantic proximity Read ↗

The SCID mouse.Semantic proximity Read ↗

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