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Article

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.

Molecular and cellular biology - 1 Jun 1993

Pergola F, Zdzienicka M Z, Lieber M R

Abstract excerpt

V(D)J recombination has been examined in several X-ray-sensitive and double-strand break repair-deficient Chinese hamster cell mutants. Signal joint formation was affected in four mutants (xrs 5, XR-1, V-3, and XR-V9B cells, representing complementation groups 1 through 4, respectively) defective in DNA double-strand break rejoining. Among these four, V-3 and XR-V9B were the most severely affected. Only in V-3...

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Identifiers

PMID: 8497262
DOI: 10.1128/mcb.13.6.3464-3471.1993
PMCID: PMC359815

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V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.PMID 8497262Read ↗

Characterization of Chinese hamster cell lines that are x-ray-sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination.Semantic proximity Read ↗

XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation.Semantic proximity Read ↗

Mammalian X ray sensitive mutants: a tool for the elucidation of the cellular response to ionizing radiation.Semantic proximity Read ↗

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Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint.Semantic proximity Read ↗

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Studies on mammalian mutants defective in rejoining double-strand breaks in DNA.Semantic proximity Read ↗

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