Article
V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.
Molecular and cellular biology - 1 Jun 1993
Pergola F, Zdzienicka M Z, Lieber M R
Abstract excerpt
V(D)J recombination has been examined in several X-ray-sensitive and double-strand break repair-deficient Chinese hamster cell mutants. Signal joint formation was affected in four mutants (xrs 5, XR-1, V-3, and XR-V9B cells, representing complementation groups 1 through 4, respectively) defective...
Topics
- Animals
- Ataxia Telangiectasia
- Base Sequence
- CHO Cells
- Cell Line
- Cricetinae
- DNA
- DNA Nucleotidyltransferases
- DNA Repair
- DNA Replication
- Exons
- Genetic Complementation Test
- Humans
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation
- Receptors, Antigen, T-Cell
- Recombination, Genetic