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Article

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.

Cell - 29 Dec 1995

Li Z, Otevrel T, Gao Y, Cheng H L, Seed B, Stamato T D, Taccioli G E, Alt F W

Abstract excerpt

The XR-1 Chinese hamster ovary cell line is impaired in DNA double-strand break repair (DSBR) and in ability to support V(D)J recombination of transiently introduced substrates. We now show that XR-1 cells support recombination-activating gene 1- and 2-mediated initiation of V(D)J recombination within a chromosomally integrated substrate, but are highly impaired in ability to complete the process by forming...

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Source

Identifiers

PMID: 8548796
DOI: 10.1016/0092-8674(95)90135-3

Genes

XRCC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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