Article
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.
Cell - 29 Dec 1995
Li Z, Otevrel T, Gao Y, Cheng H L, Seed B, Stamato T D, Taccioli G E, Alt F W
Abstract excerpt
The XR-1 Chinese hamster ovary cell line is impaired in DNA double-strand break repair (DSBR) and in ability to support V(D)J recombination of transiently introduced substrates. We now show that XR-1 cells support recombination-activating gene 1- and 2-mediated initiation of V(D)J recombination w...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- DNA
- DNA Repair
- DNA, Complementary
- DNA-Binding Proteins
- Gene Expression
- Gene Library
- Genetic Complementation Test
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Recombination, Genetic