Article
Defective repair of radiation-induced chromosomal damage in scid/scid mice.
Cytogenetics and cell genetics - 1 Jan 1992
Disney J E, Barth A L, Shultz L D
Abstract excerpt
The murine severe combined immunodeficiency (scid) mutation interferes with normal recombination of immunoglobulin and T-cell receptor genes. This immunologic defect results in a lack of fully differentiated B and T cells in scid/scid mice. Animals homozygous for the scid mutation also display in...
Topics
- Animals
- Cells, Cultured
- Chromosome Aberrations
- Chromosomes
- DNA Repair
- Dose-Response Relationship, Radiation
- Gamma Rays
- Mice
- Mice, SCID
- Mutation
