Intracellular transport of class I HLA molecules is affected by polymorphic residues in the binding groove.

doi:10.1007/BF00188789

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Article

Intracellular transport of class I HLA molecules is affected by polymorphic residues in the binding groove.

Immunogenetics - 1 Jan 1994

Salter R D

Abstract excerpt

Intracellular transport of class I MHC complexes is dependent on assembly of class I heavy chains with beta 2-microglobulin (beta 2m) and peptides. This suggests that amino acid residues of individual class I molecules which are important for their stability and transport are likely to include th...

Topics

Binding Sites
Biological Transport, Active
Cell Line
Drug Stability
Gene Expression
HLA-A Antigens
Humans
Mutagenesis, Site-Directed
Phenotype
Polymorphism, Genetic
Transfection

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