Article
Intracellular transport of class I HLA molecules is affected by polymorphic residues in the binding groove.
Immunogenetics - 1 Jan 1994
Salter R D
Abstract excerpt
Intracellular transport of class I MHC complexes is dependent on assembly of class I heavy chains with beta 2-microglobulin (beta 2m) and peptides. This suggests that amino acid residues of individual class I molecules which are important for their stability and transport are likely to include those which contribute to binding of a majority of the cleft-associated peptides. To identify such critical residues,...
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