Article
Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.
Current biology : CB - 1 Jul 1996
Lewis J W, Neisig A, Neefjes J, Elliott T
Abstract excerpt
BACKGROUND: Glycoproteins encoded by the major histocompatibility complex class I region (MHC class I) present peptide antigens to cytotoxic T cells (CTLs). Peptides are delivered to the site of MHC class I assembly by the transporter associated with antigen processing (TAP), and cell lines that...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Animals
- Binding Sites
- Biological Transport
- Cell Line
- Cell Membrane
- HLA-A2 Antigen
- Histocompatibility Antigens Class I
- Humans
- Major Histocompatibility Complex
- Phenotype
- Point Mutation
- Rabbits