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Article

Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.

Current biology : CB - 1 Jul 1996

Lewis J W, Neisig A, Neefjes J, Elliott T

Abstract excerpt

BACKGROUND: Glycoproteins encoded by the major histocompatibility complex class I region (MHC class I) present peptide antigens to cytotoxic T cells (CTLs). Peptides are delivered to the site of MHC class I assembly by the transporter associated with antigen processing (TAP), and cell lines that lack this transporter are unable to present endogenous antigens to CTLs. Although it has been shown that a fraction of...

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Identifiers

PMID: 8805302
DOI: 10.1016/s0960-9822(02)00611-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.PMID 8805302Read ↗

Increased efficiency of folding and peptide loading of mutant MHC class I molecules.Semantic proximity Read ↗

Mutant MHC class I molecules define interactions between components of the peptide-loading complex.Semantic proximity Read ↗

A single bottleneck in HLA-C assembly.Semantic proximity Read ↗

Physical and functional association of the major histocompatibility complex class I heavy chain alpha3 domain with the transporter associated with antigen processing.Semantic proximity Read ↗

An improved assembly assay for peptide binding to HLA-B*2705 and H-2K(k) class I MHC molecules.Semantic proximity Read ↗

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.Semantic proximity Read ↗

Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.Semantic proximity Read ↗

Reduced cell surface expression of HLA-C molecules correlates with restricted peptide binding and stable TAP interaction.Semantic proximity Read ↗

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides.Semantic proximity Read ↗

Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP).Semantic proximity Read ↗

Defective presentation of endogenous antigen by a cell line expressing class I molecules.Semantic proximity Read ↗

Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex.Semantic proximity Read ↗

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