Article
Intracellular transport of class I MHC molecules in antigen processing mutant cell lines.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1993
Anderson K S, Alexander J, Wei M, Cresswell P
Abstract excerpt
Intracellular transport and stability of class I MHC glycoproteins depends on the assembly of H chain, beta 2-microglobulin, and peptide. The Ag processing mutant cell lines T2 and RMA-S have defects in peptide loading of class I, resulting in reduced cell surface expression of class I molecules....
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigen-Presenting Cells
- Biological Transport
- Genes, MHC Class I
- Histocompatibility Antigens Class I
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- T-Lymphocytes, Cytotoxic
- Tumor Cells, Cultured
- beta 2-Microglobulin