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Article

Intracellular transport of class I MHC molecules in antigen processing mutant cell lines.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1993

Anderson K S, Alexander J, Wei M, Cresswell P

Abstract excerpt

Intracellular transport and stability of class I MHC glycoproteins depends on the assembly of H chain, beta 2-microglobulin, and peptide. The Ag processing mutant cell lines T2 and RMA-S have defects in peptide loading of class I, resulting in reduced cell surface expression of class I molecules. Expression of class I molecules in the murine cell line RMA-S can be induced at 26 degrees C, suggesting that they are...

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Source

Identifiers

PMID: 8376783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Intracellular transport of class I MHC molecules in antigen processing mutant cell lines.PMID 8376783Read ↗

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.Semantic proximity Read ↗

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides.Semantic proximity Read ↗

Defective presentation of endogenous antigen by a cell line expressing class I molecules.Semantic proximity Read ↗

Mutations in specific I-A(k) alpha(2) and beta(2) domain residues affect surface expression.Semantic proximity Read ↗

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.Semantic proximity Read ↗

Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter.Semantic proximity Read ↗

Empty MHC class I molecules come out in the cold.Semantic proximity Read ↗

Low temperature and peptides favor the formation of class I heterodimers on RMA-S cells at the cell surface.Semantic proximity Read ↗

DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.Semantic proximity Read ↗

Transport and expression of class I MHC glycoproteins in an antigen-processing mutant cell line.Semantic proximity Read ↗

The RMA-S lymphoma mutant; consequences of a peptide loading defect on immunological recognition and graft rejection.Semantic proximity Read ↗

Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line.Semantic proximity Read ↗

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