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Article

Mutations in specific I-A(k) alpha(2) and beta(2) domain residues affect surface expression.

International immunology - 1 Jun 2000

Lang M L, Yadati S, Seeley E S, Nydam T, Wade T K, Gabriel J L, Yeaman G, Barisas B G, Wade W F

Abstract excerpt

A previous investigation demonstrated that several mutations in class II dimer-of-dimers contact residues interfere with antigen presentation by transfectants but not with plasma membrane expression of the mutant class II. In the present study we examined other class II mutations in this region that did inhibit plasma membrane expression of mutant class II molecules. Molecules containing both mutations H alpha...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10837405
DOI: 10.1093/intimm/12.6.777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Mutations in specific I-A(k) alpha(2) and beta(2) domain residues affect surface expression.PMID 10837405Read ↗

DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.Semantic proximity Read ↗

Deletion of a C-terminal sequence of the class II-associated invariant chain abrogates invariant chains oligomer formation and class II antigen presentation.Semantic proximity Read ↗

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Impaired antigen presentation by murine I-Ad class II MHC molecules expressed in normal and HLA-DM-defective human B cell lines.Semantic proximity Read ↗

Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal.Semantic proximity Read ↗

Expression of invariant chain can cause an allele-dependent increase in the surface expression of MHC class I molecules.Semantic proximity Read ↗

Invariant chain association with MHC class I: preference for HLA class I/beta 2-microglobulin heterodimers, specificity, and influence of the MHC peptide-binding groove.Semantic proximity Read ↗

Intracellular transport of class I MHC molecules in antigen processing mutant cell lines.Semantic proximity Read ↗

Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.Semantic proximity Read ↗

Mutations in MHC class II dimer of dimers contact residues: effects on antigen presentation.Semantic proximity Read ↗

Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties.Semantic proximity Read ↗

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