Article
MHC allele-specific molecular features determine peptide/HLA-A2 conformations that are recognized by HLA-A2-restricted T cell receptors.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2002
Wang Zichun, Turner Richard, Baker Brian M, Biddison William E
Abstract excerpt
The structures of alphabeta TCRs bound to complexes of class I MHC molecules and peptide show that the TCRs make multiple contacts with the alpha1 and alpha2 helixes of the MHC. Previously we have shown that the A6 TCR in complex with the HLA-A2/Tax peptide has 15 contact sites on HLA-A2. Single amino acid mutagenesis of these contact sites demonstrated that mutation of only three amino acids clustered on the...
Topics
- Alleles
- Amino Acid Substitution
- Cell Line
- Cytomegalovirus
- Cytotoxicity Tests, Immunologic
- Epitopes
- Gene Products, tax
- HLA-A2 Antigen
- Humans
- Melanoma
- Membrane Glycoproteins
- Mutagenesis, Site-Directed
- Neoplasm Proteins