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Article

Pocket mutations of HLA-B27 show that anchor residues act cumulatively to stabilize peptide binding.

Biochemistry - 21 Jun 1994

Parker K C, Biddison W E, Coligan J E

Abstract excerpt

Major histocompatibility complex (MHC) class I molecules bind endogenously synthesized peptides for presentation to cytotoxic T-cells. The human class I molecule HLA-B27 consists of a trimolecular complex containing the HLA-B27 heavy chain, a peptide that is usually nine amino acid residues (aa) long, and beta 2-microglobulin (beta 2m). The key interactions for peptide selectivity are between Glu-45, which forms...

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Identifiers

PMID: 8011638
DOI: 10.1021/bi00190a029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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