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Article

Polymorphism at position 97 in MHC class I molecules affects peptide specificity, cell surface stability, and affinity for beta2-microglobulin.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2002

Smith Ruth A, Myers Nancy B, Robinson Melanie, Hansen Ted H, Lee David R

Abstract excerpt

The two mouse MHC class I alleles, L(d) and L(q), share complete amino acid sequence identity except in the alpha2 domain, where they differ at six positions. Despite their similarity, L(q) has a stronger association with beta2-microglobulin (beta2m), is expressed at higher levels on the cell surface, demonstrates an increased cell surface half-life, and has fewer open forms on the cell surface than L(d). To...

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Identifiers

PMID: 12218127
DOI: 10.4049/jimmunol.169.6.3105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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