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Article

Structural basis for the restoration of TCR recognition of an MHC allelic variant by peptide secondary anchor substitution.

The Journal of experimental medicine - 6 Dec 2004

Miley Michael J, Messaoudi Ilhem, Metzner Beatrix M, Wu Yudong, Nikolich-Zugich Janko, Fremont Daved H

Abstract excerpt

Major histocompatibility complex (MHC) class I variants H-2K(b) and H-2K(bm8) differ primarily in the B pocket of the peptide-binding groove, which serves to sequester the P2 secondary anchor residue. This polymorphism determines resistance to lethal herpes simplex virus (HSV-1) infection by modulating T cell responses to the immunodominant glycoprotein B(498-505) epitope, HSV8. We studied the molecular basis of...

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Identifiers

PMID: 15557346
DOI: 10.1084/jem.20040217
PMCID: PMC2211956

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Source receipt: pubmed, retrieved 7 Sept 2026.

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