Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line.

Article

Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1994

Greenwood R, Shimizu Y, Sekhon G S, DeMars R

Abstract excerpt

Human B cell line .220 has a novel defect in HLA class I cell surface expression. Mutant .220 was derived from .184TGr, from which both copies of HLA-A and -B are deleted, and has less surface HLA-C than .184TGr. Transfer of class I genes into .220 revealed allele-specific reductions in surface e...

Topics

Alleles
B-Lymphocytes
Blotting, Northern
Cell Fusion
Cell Line
HLA Antigens
Histocompatibility Antigens Class I
Humans
Mutation
Protein Biosynthesis
RNA, Messenger
Transfection

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