Article
Genetic alterations associated with the evolution and progression of astrocytic brain tumours.
Virchows Archiv : an international journal of pathology - 1 Jan 1995
Ohgaki H, Schäuble B, zur Hausen A, von Ammon K, Kleihues P
Abstract excerpt
Diffusely infiltrating low-grade astrocytomas (WHO grade II) have an intrinsic tendency for progression to anaplastic astrocytoma (WHO grade III) and glioblastoma (WHO grade IV). This change is due to the sequential acquisition of genetic alterations, several of which have recently been identified. In low-grade astrocytomas, p53 mutations with or without loss of heterozygosity on chromosome 17p are the principal...
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