Article
Molecular pathogenesis of pediatric astrocytic tumors.
Neuro-oncology - 1 Apr 2007
Nakamura Mitsutoshi, Shimada Keiji, Ishida Eiwa, Higuchi Tomonori, Nakase Hiroyuki, Sakaki Toshisuke, Konishi Noboru
Abstract excerpt
Astrocytomas are the most common pediatric brain tumors, accounting for 7%-8% of all childhood cancers. Relatively few studies have been performed on their molecular properties; therefore, classification of pediatric astrocytic tumors into genetic subtypes similar to that of adult tumors remains to be defined. Here, we report an extensive characterization of 44 pediatric astrocytomas--16 diffuse astrocytomas (WHO...
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