Article
TP53 gene mutations and 17p deletions in human astrocytomas.
Genes, chromosomes & cancer - 1 Sept 1991
Chung R, Whaley J, Kley N, Anderson K, Louis D, Menon A, Hettlich C, Freiman R, Hedley-Whyte E T, Martuza R
Abstract excerpt
Astrocytomas, including the most malignant form, glioblastoma multiforme, are the most frequent and deadly primary tumors of the human nervous system. Recent molecular genetic analyses of astrocytomas have demonstrated frequent chromosome 17 deletions involving the telomeric region of the short arm (17p12-pter). This region contains a candidate tumor suppressor gene, TP53, which has recently been implicated in...
Topics
- Adult
- Antibodies, Monoclonal
- Astrocytoma
- Base Sequence
- Blotting, Southern
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Glioblastoma
- Humans