Article
TP53 and p53 statuses and their clinical impact in diffuse low grade gliomas.
Journal of neuro-oncology - 1 May 2014
Gillet Emeline, Alentorn Agusti, Doukouré Brahima, Mundwiller Emeline, van Thuijl Hinke F, van Thuij Hinke, Reijneveld Jaap C, Medina José Alfonso Meza, Liou Amélie, Marie Yannick, Mokhtari Karima, Hoang-Xuan Khê, Sanson Marc, Delattre Jean-Yves, Idbaih Ahmed
Abstract excerpt
TP53 is a pivotal gene frequently mutated in diffuse gliomas and particularly in astrocytic tumors. The majority of studies dedicated to TP53 in gliomas were focused on mutational hotspots located in exons 5-8. Recent studies have suggested that TP53 is also mutated outside the classic mutational hotspots reported in gliomas. Therefore, we have sequenced all TP53 coding exons in a retrospective series of 61 low...
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