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Article

Chromosome 10 and 17 deletions and p53 gene mutations in Thai patients with astrocytomas.

Oncology reports - 1 Jan 2004

Put-Ti-Noi Supawadee, Petmitr Songsak, Chanyavanich Voravut, Sangruji Tumtip, Theerapuncharoen Veerasak, Hayashi Kenshi, Thangnipon Wipawan

Abstract excerpt

The tumor suppressor gene locus is known to be partly responsible for the tumorigenesis of sporadic gliomas, but the genetic events that drive the neoplastic process of this tumor remain largely unknown. We correlated the results of loss of heterozygosity (LOH) analysis on chromosomes 10 and 17 and a point mutation analysis of a tumor suppressor gene, p53, in 21 patients with astrocytomas at different stages. LOH...

Topics

Adult
Aged
Astrocytoma
Base Sequence
Chromosome Deletion
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 17
DNA Mutational Analysis
DNA, Neoplasm
Exons
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glioblastoma

Humans

Loss of Heterozygosity

Male

Microsatellite Repeats

Middle Aged

Mutation

Source

Identifiers

PMID: 14654927

Provenance

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