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Article

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

Cancer research - 1 Feb 1992

Fults D, Brockmeyer D, Tullous M W, Pedone C A, Cawthon R M

Abstract excerpt

The human brain tumor, astrocytoma, typically progresses through three histopathologically defined stages with the passage of time: one premalignant stage, low-grade astrocytoma; and two malignant stages, anaplastic astrocytoma and glioblastoma multiforme. We correlated the results of a sequence analysis of the tumor suppressor gene, p53, and a restriction fragment length polymorphism analysis of chromosomes 17...

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PMID: 1346255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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