p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

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Article

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

Cancer research - 1 Feb 1992

Fults D, Brockmeyer D, Tullous M W, Pedone C A, Cawthon R M

Abstract excerpt

The human brain tumor, astrocytoma, typically progresses through three histopathologically defined stages with the passage of time: one premalignant stage, low-grade astrocytoma; and two malignant stages, anaplastic astrocytoma and glioblastoma multiforme. We correlated the results of a sequence...

Topics

Amino Acid Sequence
Astrocytoma
Base Sequence
Brain Neoplasms
Chromosome Deletion
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 17
Cloning, Molecular
Codon
DNA, Neoplasm
Exons
Genes, p53
Genetic Markers
Glioblastoma
Humans
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides

Source

Open in PubMed

Identifiers

PMID: 1346255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1346255-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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