Article
Genetic alterations associated with glioma progression.
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 1994
Kleihues P, Lübbe J, Watanabe K, von Ammon K, Ohgaki H
Abstract excerpt
Among tumours of the nervous system, mutations of the p53 tumour suppressor gene are largely restricted to neoplasms of astrocytic origin. These are the most common human brain tumours and span a wide range of biologic behavior, from the slowly growing low-grade astrocytoma (WHO Grade II) to anaplastic astrocytoma (WHO Grade III) and, ultimately, the glioblastoma multiforme (WHO Grade IV). In low grade...
Topics
- Astrocytoma
- Brain Neoplasms
- Carrier Proteins
- Chromosome Deletion
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p16
- ErbB Receptors
- Genes, Tumor Suppressor
- Genes, p53
- Glioblastoma