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Article

Progressive B-cell chronic lymphocytic leukaemia frequently exhibits aberrant p53 expression.

International journal of cancer - 15 Aug 1994

Aguilar-Santelises M, Magnusson K P, Wiman K G, Mellstedt H, Jondal M

Abstract excerpt

We have analysed the p53 status in non-progressive and progressive chronic B-cell leukemia (B-CLL) by ELISA, immunoprecipitation, FACS and cDNA sequencing in relation to in vitro proliferation in response to Staphylococcus aureus strain Cowan I (SAC) and IL-2. In FACS, cells from progressive leukaemia were found to over-express p53 with a conformation recognized by PAB240. In a PAb240-based ELISA, 60% of...

Topics

Adult
Aged
Base Sequence
Enzyme-Linked Immunosorbent Assay
Female
Genes, p53
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Lymphocyte Activation
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Precipitin Tests

Source

Identifiers

PMID: 8056442
DOI: 10.1002/ijc.2910580403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8056442-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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