Altered conformation of the p53 protein in myeloid leukemia cells and mitogen-stimulated normal blood cells.

Article

Altered conformation of the p53 protein in myeloid leukemia cells and mitogen-stimulated normal blood cells.

Oncogene - 1 Aug 1992

Zhang W, Hu G, Estey E, Hester J, Deisseroth A

Abstract excerpt

Expression of the normal p53 gene promotes cell differentiation, maturation and apoptosis. The mutant p53 gene, which does not function normally, is frequently expressed at elevated levels in tumor cells [for review see Lane, D.P. & Benchimol, S. (1990). Genes Dev., 4, 1-8]. We have analysed the...

Topics

Acute Disease
DNA, Single-Stranded
Genes, p53
Humans
Leukemia, Myeloid
Lymphocyte Activation
Lymphocytes
Mutation
Polymorphism, Genetic
Precipitin Tests
Protein Conformation
Tumor Suppressor Protein p53

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