Article
Significance of p53 mutations in patients with chronic lymphocytic leukemia: a sequential study of 30 patients.
Cancer - 15 Jan 2001
Barnabas N, Shurafa M, Van Dyke D L, Wolman S R, Clark D, Worsham M J
Abstract excerpt
BACKGROUND: In patients with B-cell chronic lymphocytic leukemia (CLL), considerable disease heterogeneity within clinical stages necessitates the search for relevant prognostic indicators, particularly those that may help to determine the need for early therapeutic intervention. In the current study, the authors investigated the role of p53 mutations and chromosomal abnormalities in 30 patients with CLL....
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