Addition of fresh medium induces cell cycle and conformation changes in p53, a tumour suppressor protein.

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Article

Addition of fresh medium induces cell cycle and conformation changes in p53, a tumour suppressor protein.

Oncogene - 1 Nov 1990

Milner J, Watson J V

Abstract excerpt

Using analytical flow cytometry we have monitored changes in the conformation of p53 through the cell cycle under different conditions of cell growth. Conformational variants of murine p53 are characterized by reactivity with monoclonal antibodies PAb246, PAb248 and PAb421. In proliferating cells...

Topics

Animals
Antigens, Viral, Tumor
Blood
Cell Cycle
Cell Division
Cell Line
Cell Line, Transformed
Chromatin
Culture Media
Flow Cytometry
Fluorescent Antibody Technique
Immunoblotting
Immunosorbent Techniques
Mice
Mice, Inbred BALB C
Mutation
Nuclear Matrix
Protein Conformation

Source

Open in PubMed

Identifiers

PMID: 2176282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2176282-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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