Article
p53 abnormalities in CLL are associated with excess of prolymphocytes and poor prognosis.
British journal of haematology - 1 Dec 1997
Lens D, Dyer M J, Garcia-Marco J M, De Schouwer P J, Hamoudi R A, Jones D, Farahat N, Matutes E, Catovsky D
Abstract excerpt
To determine the role of the p53 gene in chronic lymphocytic leukaemia (CLL) and its possible involvement in the pathogenesis of a progressive form of CLL characterized by > 10%, prolymphocytes (CLL/PL), we selected 32 cases, 17 with typical morphology and 15 CLL/PL. The extent of inactivation of...
Topics
- Blotting, Southern
- Gene Expression
- Genes, p53
- Humans
- Immunohistochemistry
- Leukemia, Lymphocytic, Chronic, B-Cell
- Leukemia, Prolymphocytic
- Loss of Heterozygosity
- Mutation
- Polymerase Chain Reaction
- Prognosis
- Survival Analysis
- Survival Rate