Article
Mutant p53 detected in a majority of Burkitt lymphoma cell lines by monoclonal antibody PAb240.
Oncogene - 1 Sept 1991
Wiman K G, Magnusson K P, Ramqvist T, Klein G
Abstract excerpt
The status of the p53 gene in lymphoblastoid cell lines (LCLs) and Burkitt lymphoma cell lines (BLs) was investigated. Southern blot analysis demonstrated that no major deletions or rearrangements had occurred in the p53 gene in any of the cell lines. The p53 protein was examined by immunoprecipitation using two monoclonal anti-p53 antibodies. PAb1801 recognizes both wild-type and mutant p53. PAb240 reacts...
Topics
- Antibodies, Monoclonal
- Blotting, Southern
- Burkitt Lymphoma
- Cell Line
- Chromosome Deletion
- DNA, Neoplasm
- Gene Rearrangement
- Humans
- Mutation
- Tumor Suppressor Protein p53