Article
p53 expression in non small cell lung cancer: clinical and biological correlations.
Anticancer research - 1 Jan 2000
Fontanini G, Bigini D, Vignati S, Macchiarini P, Pepe S, Angeletti C A, Pingitore R, Squartini F
Abstract excerpt
p53 is a tumor suppressor gene, located in the short arm of chromosome 17, which encodes for a nuclear protein involved in the control of cellular growth. Mutations in p53 gene are the most common genetic alterations in a several human cancers, including Non Small Cell Lung Cancer (NSCLC). However, up to now, the role of p53 in the tumour's behaviour and its progression has not been completely clear. We performed...
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