Article
A new mutational hot-spot in the p53 gene in human hepatocellular carcinoma.
Journal of hepatology - 1 Apr 1994
Diamantis I D, McGandy C, Chen T J, Liaw Y F, Gudat F, Bianchi L
Abstract excerpt
Mutations in the p53 gene are frequent genetic alterations in human hepatocellular carcinoma. We have examined 38 hepatocellular carcinoma cases from Taiwan for the presence of p53 alterations in exons 5-8 of the gene using the single-stranded conformational polymorphism method and direct sequencing of polymerase chain reaction products. Using the single-stranded conformational polymorphism method, we found...
Topics
- Base Sequence
- Carcinoma, Hepatocellular
- DNA, Single-Stranded
- Exons
- Genes, p53
- Humans
- Liver Neoplasms
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Polymerase Chain Reaction