Article
p53 hot-spot mutational analysis in advanced Western gallbladder carcinoma.
World journal of surgery - 1 Sept 1997
Jonas S, Springmeier G, Tauber R, Wiedenmann B, Gessner R, Kling N, Lobeck H, Fieger C, Bechstein W O, Neuhaus P
Abstract excerpt
In gallbladder carcinoma, studies on the prime target of genetic alterations and gene therapy in human gallbladder malignancies, the p53 tumor suppressor gene, have been focusing on this gene's immunohistochemical detection. From November 1991 to October 1993, seven patients suffering from gallbl...
Topics
- Adenocarcinoma
- Aged
- Carcinoma
- Carcinoma, Squamous Cell
- Cloning, Molecular
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Urinary Bladder Neoplasms
- White People