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Article

Mutation of p53 gene in hepatocellular carcinoma in Taiwan.

Cancer research - 1 Nov 1992

Sheu J C, Huang G T, Lee P H, Chung J C, Chou H C, Lai M Y, Wang J T, Lee H S, Shih L N, Yang P M

Abstract excerpt

To elucidate the role of p53 mutation in hepatocarcinogenesis in Taiwan, a hepatitis B viral infection hyperendemic area, exons 5 to 8 of the p53 gene in the tumor tissue of 61 hepatocellular carcinomas were amplified and sequenced. A total of 20 cases (32.8%) were found to have mutations; 36.6% (15 of 41) for the hepatitis B surface antigen positive group and 25.0% (5 of 20) for the hepatitis B surface antigen...

Topics

Adult
Aged
Amino Acid Sequence
Base Sequence
Carcinoma, Hepatocellular
Exons
Female
Genes, p53
Hepatitis B Surface Antigens
Humans
Liver Neoplasms
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Mutation

Taiwan

Source

Identifiers

PMID: 1327523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1327523-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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