Article
TP53 tumor suppressor gene: a model for investigating human mutagenesis.
Genes, chromosomes & cancer - 1 Jan 1992
Caron de Fromentel C, Soussi T
Abstract excerpt
More than 350 independent point mutations of the TP53 gene, found in a wide variety of human cancers, were compiled and analysed. From this study, we confirm the presence of four hot-spot regions which colocalize with some highly conserved domains of the protein. We also define a new hot-spot region which is observed predominantly in lung tumors. Analysis of the mutational events suggests the direct involvement...
Topics
- Amino Acid Sequence
- Codon
- DNA, Neoplasm
- Genes, p53
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Neoplasm Proteins
- Neoplasms
- Tumor Suppressor Protein p53