Article
A mutational hot spot in the p53 gene is associated with hepatoblastomas.
International journal of cancer - 16 Mar 1995
Oda H, Nakatsuru Y, Imai Y, Sugimura H, Ishikawa T
Abstract excerpt
Hepatoblastomas generally appear in children aged 2 or 3 years old and arise from apparently normal, non-cirrhotic liver. To elucidate any possible role of p53 mutations in their genesis, we amplified and sequenced exons 5 to 8 of the p53 gene in 10 cases of hepatoblastoma. Somatic mutations were...
Topics
- Base Sequence
- Child
- Child, Preschool
- Exons
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Hepatoblastoma
- Humans
- Infant
- Liver Neoplasms
- Male
- Molecular Sequence Data
- Mutation
- Sequence Analysis, DNA
- Tumor Suppressor Protein p53