Mutational hotspot in the p53 gene in human hepatocellular carcinomas.

doi:10.1038/350427a0

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Article

Mutational hotspot in the p53 gene in human hepatocellular carcinomas.

Nature - 4 Apr 1991

Hsu I C, Metcalf R A, Sun T, Welsh J A, Wang N J, Harris C C

Abstract excerpt

Human hepatocellular carcinomas (HCC) from patients in Qidong, an area of high incidence in China, in which both hepatitis B virus and aflatoxin B1 are risk factors, were analysed for mutations in p53, a putative tumour-suppressor gene. Eight of the 16 HCC had a point mutation at the third base p...

Topics

Base Sequence
Carcinoma, Hepatocellular
China
Exons
Genes, Tumor Suppressor
Humans
Liver Neoplasms
Molecular Sequence Data
Mutation
Oligonucleotides
Polymerase Chain Reaction
Risk Factors
Tumor Suppressor Protein p53

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