Article
Mutational hotspot in the p53 gene in human hepatocellular carcinomas.
Nature - 4 Apr 1991
Hsu I C, Metcalf R A, Sun T, Welsh J A, Wang N J, Harris C C
Abstract excerpt
Human hepatocellular carcinomas (HCC) from patients in Qidong, an area of high incidence in China, in which both hepatitis B virus and aflatoxin B1 are risk factors, were analysed for mutations in p53, a putative tumour-suppressor gene. Eight of the 16 HCC had a point mutation at the third base position of codon 249. The G----T transversion in seven HCC DNA samples and the G----C transversion in the other HCC are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.