Article
Aberrations of p53 gene in human hepatocellular carcinoma from China.
Carcinogenesis - 1 Feb 1993
Li D, Cao Y, He L, Wang N J, Gu J R
Abstract excerpt
Allele losses and mutations have been examined in 38 cases of primary hepatocellular carcinomas (HCC) from different geographic areas of China by Southern, single-strand conformational polymorphism (SSCP) and direct DNA sequencing analyses. Two of 12 samples from Qi-Dong and six of 18 HCCs from Shanghai showed loss of heterozygosity (LOH) at the loci on chromosome 17p13.3. All of the nine mutations in the p53...
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