Article
Entry of B lymphocytes into the persistent cell pool in non-immunized mice is not accompanied by somatic mutation of VH genes.
European journal of immunology - 1 Jul 1994
Chies J A, Lembezat M P, Freitas A A
Abstract excerpt
In this study we compare VH-gene repertoires of short-lived and persistent B lymphocytes in normal nonimmunized mice. Enriched populations of persistent peripheral B cells were obtained in vivo either by (i) repeated injections with hydroxyurea or (ii) maintained ganciclovir administration to her...
Topics
- Animals
- B-Lymphocyte Subsets
- Base Sequence
- Cell Survival
- Ganciclovir
- Gene Expression
- Hydroxyurea
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction